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PB-22 and 5F-PB-22 have been the first synthetic cannabinoids to include a quinoline substructure and an ester linkage. These compounds are imagined to are synthesized Together with the intention of constructing a artificial cannabinoid prodrug, which could boost absorption and confound detection. Ester bonds are quickly biodegradable through spontaneous or endogenous, nonspecific esterase hydrolysis, that has been typically used in medicinal chemistry to create ester prodrugs.
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